D-α-Hydroxyglutaric acid disodium

Supplier MedChemExpress
Product # HY-100542-25 mg
CAS # 103404-90-6
Pricing 25 mg, USD $84.0
Synonyms Disodium (R)-2-hydroxyglutarate
MWt 192.08
Formula C₅H₆Na₂O₅
Biological Activity D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].
Purity ≥98.0%
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