PSB 0777 ammonium salt
PSB 0777 is a potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors), with subtype selectivity for A2A receptors over A1, A2B and A3 receptors (Ki ≥ 10 000 nM for rat A1, human A2B and human A3 receptors). The beneficial effects of PSB-0777 on inflammatory parameters were prevented by the pharmacological blockade of A2A receptors. No adverse cardiovascular events were observed upon PSB-0777 administration. The novel A2A receptor agonist PSB-0777 could represent the base for the development of innovative pharmacological entities able to act in an event-specific and site-specific manner.
| Supplier | BOC Sciences |
|---|---|
| Product # | 2122196-16-9 |
| Pricing | Inquire |
| Cas | 2122196-16-9 |
| Molecular Weight | 500.55 |
| Molecular Formula | C18H20N5O7S2.NH4 |
| Canonical SMILES | C1=CC(=CC=C1CCSC2=NC3=C(C(=N2)N)N=CN3C4C(C(C(O4)CO)O)O)S(=O)(=O)O.N |