Recombinant Human PDGFRB, GST-tagged, Active

PDGFRβ (platelet-derived growth factor receptor) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRβ deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function. However, absence of PDGFRβ has no impact on major blood vessels and the heart. PDGFRβexpression and activity is elevated in several cancers and inhibition of PDGFRβ activity blocks progression of renal carcinoma in an animal model.

• Supplier: Creative Biomart
• Product #: PDGFRB-386H