GSK-J4
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15648B-50 mg |
| CAS # | 1373423-53-0 |
| Pricing | 50 mg, USD $420.0 |
| Biological Activity | GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1[1][2][3]. GSK-J4 induces endoplasmic reticulum stress-related apoptosis[4]. |
| Purity | ≥98.0% |
| MWt | 417.5 |
| Formula | C₂₄H₂₇N₅O₂ |