Bisindolylmaleimide VIII acetate
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-129624A-5 mg |
| CAS # | 138516-31-1 |
| Pricing | 5 mg, USD $260.0 |
| Biological Activity | Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively[1]. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases[2]. |
| Synonyms | Ro 31-7549 acetate; Bis VIII acetate |
| MWt | 458.51 |
| Formula | C₂₆H₂₆N₄O₄ |