Dihydrokainic acid
Dihydrokainic acid is an inhibitor of excitatory amino acid transporter 2 (EAAT2). EEAT2 exhibits anti-depressant-like activity --- an effect that is blocked by the AMPA receptor antagonist NBQX and the serotonin (5-HT) receptor subtype 5-HT1A antagonist WAY-100635. It also increases glutamate and serotonin levels and the expression of c-Fos in the dorsal raphe nucleus. It also impairs memory acquisition, consolidation, and retrieval.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD792 |
| CAS # | 52497-36-6 |
| Pricing | Customizable size, Inquiry |
| Synonym | Dihydrokainic acid, DHK |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C10H17NO4 |
| Exact Mass | 215.1158 |
| Molecular Weight | 215.249 |
| Elemental Analysis | C, 55.80; H, 7.96; N, 6.51; O, 29.73 |
| IUPAC/Chemical Name | (2S,3S,4R)-2-carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid |
| InChi Key | JQPDCKOQOOQUSC-OOZYFLPDSA-N |
| InChi Code | InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 |
| SMILES Code | OC([C@@H]1[C@@H](CC(O)=O)[C@@H](C(C)C)CN1)=O |
| Appearance | Solid powder |
| Purity | >95% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |