Duocarmycin SA

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Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.

Supplier	BOC Sciences
Product #	130288-24-3
Pricing	Inquire
Cas	130288-24-3
Molecular Weight	477.47
Molecular Formula	C25H23N3O7
Canonical SMILES	COC1=C(C(=C2C(=C1)C=C(N2)C(=O)N3CC4CC45C3=CC(=O)C6=C5C=C(N6)C(=O)OC)OC)OC

Citations for this product:

Identification of novel mutational signatures in Asian oral squamous cell carcinomas associated with bacterial infections

Arnoud Boot, et al., bioRxiv - Genomics 2019

Quote: ... Duocarmycin SA (CAS: 130288-24-3) was obtained from BOC Sciences (New York, USA).

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