SNIPER(BRD)-1
SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].
| Supplier | BOC Sciences |
|---|---|
| Product # | 2095244-54-3 |
| Pricing | Inquire |
| Cas | 2095244-54-3 |
| Molecular Weight | 1056.73 |
| Molecular Formula | C53H66ClN9O8S2 |
| Canonical SMILES | O=C(C=1N=C(SC1)C2N(C(=O)C(NC(=O)C(NC)C)C3CCCCC3)CCC2)C=4C=CC=C(OCCOCCOCCOCCNC(=O)CC5N=C(C=6C=CC(Cl)=CC6)C7=C(SC(=C7C)C)N8C(=NN=C85)C)C4 |