A-77636 hydrochloride
A-77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist. In a battery of receptor binding assays, A-77636 shows the highest affinity (pKi = 7.40 +/- 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 is an agonist at the dopamine D1 receptors in the fish retina (pEC50 = 8.13; EC50 = 1.1 nM; intrinsic activity = 102% of dopamine) and the rat caudate-putamen (pEC50 = 8.97; intrinsic activity = 134% of dopamine). When tested in marmosets treated with MPTP to induce a parkinsonian-like state, A-77636 increases locomotor activity and decreases the severity of the parkinsonian-like symptoms: the compound is active after either subcutaneous or oral administration.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD042 |
| CAS # | 145307-34-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | A-77636 hydrochloride; A77636 hydrochloride; A77636 hydrochloride |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H28ClNO3 |
| Exact Mass | 365.1758 |
| Molecular Weight | 365.898 |
| Elemental Analysis | C, 65.65; H, 7.71; Cl, 9.69; N, 3.83; O, 13.12 |
| IUPAC/Chemical Name | (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol Hydrochloride |
| InChi Key | BWHPNJVKFAPVOG-QYFJGNGUSA-N |
| InChi Code | InChI=1S/C20H27NO3.ClH/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H/t11?,12?,13?,17-,18-,20?;/m0./s1 |
| SMILES Code | OC1=C(O)C=CC2=C1C[C@@H](C34CC5CC(C4)CC(C5)C3)O[C@H]2CN.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |