Glyceryl Behenate
Glyceryl behenate occurs as a fine white-yellow powder, as a hard waxy mass or pellet, or as white or almost white unctuous flakes. It has a faint odor.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0471 |
| Pricing | , Inquire for price |
| product1 | Pharmaceutical Excipients |
| Applications | Glyceryl behenate is used in cosmetics, foods, and oral pharmaceutical formulations.In pharmaceutical formulations, glyceryl behenate is mainly used as a lubricant in the preparation of oral tablets and capsules. It has good binding properties, it does not affect tablet hardness and is unaffected by mixing or production parameters. Glyceryl behenate has been investigated for the encapsulation of various drugs such as retinoids. It has also been investigated for use in the preparation of sustained-release tablets; as a matrix-forming agent for the controlled release of water-soluble drugs; and it can also be used as a hot-melt coating agent sprayed onto a powder or drug-loaded sugar beads and granules. It may also be incorporated via extrusion/spheronization into pellets, which can be further compressed into tablets. |
| Molecular Weight | / |
| Safety | Glyceryl behenate is used in cosmetics, foods and oral pharmaceutical formulations, and is generally regarded as a relatively nonirritant and nontoxic material. The US Cosmetic Ingredients Review Expert Panel evaluated glyceryl behenate and concluded that it is safe for use in cosmetic formulations in present practices of use and concentration. LD50 (mouse, oral): 5 g/kg |
| Incompatibilities | / |
| Synonyms | Compritol 888 ATO; 2, 3-dihydroxypropyl docosanoate; docosanoic acid, 2, 3-dihydroxypropyl ester; E471; glycerol behenate; glyceroli dibehenas; glyceryl monobehenate. |
| CAS Number | 30233-64-8 |
| Category | Binder Excipients |
| Chemical Name | Docosanoic acid, monoester with glycerin [30233-64-8] (glyceryl behenate) |
| Grade | Pharmceutical Excipients |
| Administration route | Oral |
| Dosage Form | Oral capsules, tablets, and suspensions |
| Stability and Storage Conditions | Glyceryl behenate should be stored in a tightly closed container, at a temperature less than 35℃. |
| Source and Preparation | Glyceryl behenate is prepared by the esterification of glycerin by behenic acid (C22 fatty acid) without the use of catalysts. In the case of Compritol 888 ATO (Gattefosse'), raw materials used are of vegetable origin, and the esterified material is atomized by spray cooling. |