Dexniguldipine (free base)
Dexniguldipine (free base) is the (+)-enantiomer of the dihydropyridine derivate niguldipine. Dexniguldipine showed a binding affinity to the P-glycoprotein and therefore it is to be assumed to block the P-glycoprotein pumping mechanism and to modulate multidrug resistance. ( NCI)
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD768 |
| CAS # | 120054-86-6 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | Dexniguldipine (free base); |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C36H39N3O6 |
| Exact Mass | 609.2839 |
| Molecular Weight | 609.723 |
| Elemental Analysis | C, 70.92; H, 6.45; N, 6.89; O, 15.74 |
| IUPAC/Chemical Name | ( )-(R)-3-(4,4-Diphenylpiperidino)propyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate. |
| InChi Key | SVJMLYUFVDMUHP-MGBGTMOVSA-N |
| InChi Code | InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3/t33-/m1/s1 |
| SMILES Code | O=C(C1=C(C)NC(C)=C(C(OCCCN2CCC(C3=CC=CC=C3)(C4=CC=CC=C4)CC2)=O)[C@@H]1C5=CC=CC([N+]([O-])=O)=C5)OC |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |