L-655708
L-655708, also known as FG-8094, is a nootropic drug. L-655708 acts as a subtype-selective inverse agonist at the α5 subtype of the benzodiazepine binding site on the GABAA receptor. A radiolabelled form of L-655708 was used to map the distribution of the GABAA α5 subtype in the brain. L-655708 was indeed found to produce improved cognitive performance in animal studies, without producing the side effect of convulsions which is produced by non-selective inverse agonists like DMCM.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD951 |
| CAS # | 130477-52-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | L-655708; L655708; L 655708; L-655,708; L655,708; L 655,708; FG-8094; FG 8094; FG8094. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H19N3O4 |
| Exact Mass | 341.1376 |
| Molecular Weight | 341.367 |
| Elemental Analysis | C, 63.33; H, 5.61; N, 12.31; O, 18.75 |
| IUPAC/Chemical Name | ethyl (13aS)-7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate |
| InChi Key | YKYOQIXTECBVBB-AWEZNQCLSA-N |
| InChi Code | InChI=1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 |
| SMILES Code | O=C(C1=C([C@@]2([H])N3CCC2)N(C=N1)C4=CC=C(OC)C=C4C3=O)OCC |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |