Daridorexant mesylate
Daridorexant, also known as Nemorexant and ACT541468, is a new dual orexin receptor antagonist, used in the treatment of Insomnia Disorder in Adult Patients. By specific binding to both orexin receptors, daridorexant inhibits the actions of the wake-promoting orexin (also called hypocretin) neuropeptides. This mechanism avoids a more widespread inhibition of neuronal pathways and associated side effects that are intrinsic to positive allosteric GABA-A receptor modulators.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1280 |
| CAS # | Daridorexant mesylate |
| Pricing | Customizable size, Inquiry |
| Synonym | Daridorexant; Daridorexant hydrochloride; Daridorexant HCl; ACT541468; ACT 541468; ACT-541468; Nemorexant; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C24H27ClN6O5S |
| Molecular Weight | 547.03 |
| Elemental Analysis | C, 52.70; H, 4.98; Cl, 6.48; N, 15.36; O, 14.62; S, 5.86 |
| IUPAC/Chemical Name | Methanone, ((2S)-2-(6-chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)-, mesylate |
| InChi Key | VMOSCTOMUNHUKN-BQAIUKQQSA-N |
| InChi Code | InChI=1S/C23H23ClN6O2.CH4O3S/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30;1-5(2,3)4/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28);1H3,(H,2,3,4)/t23-;/m0./s1 |
| SMILES Code | O=C(N1[C@](C)(C2=NC3=CC=C(Cl)C(C)=C3N2)CCC1)C4=CC(OC)=CC=C4N5N=CC=N5.OS(=O)(C)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |