Recombinant Anti-human SNCA Intrabody [(D-Arg)9]
Recombinant anti-SNCA intrabody linked to (D-Arg)9 works within cells to bind human monomeric wild-type SNCA, expressed in E. coli cells. The intrabody stabilizes detergent-soluble monomeric syn and inhibits the formation of detergent-insoluble high-molecular-weight syn species. In addition, the intrabody ameliorates the decreased cell adhesion that characterizes the syn-overexpressing cells. Anti-SNCA intrabodies may represent novel molecular therapeutics for synucleinopathies, with implications for other neurodegenerative disorders caused by misfolded accumulated proteins.
| Supplier | Creative Biolabs |
|---|---|
| Product # | IAB-B031(A) |
| Pricing | Inquiry |
| Host | human |
| Target | SNCA |
| Species Reactivity | human |
| Type | scFv-(D-Arg)9 |
| Applications | Antibody assay: Flow Cytometry; Immunofluorescence; Functional studies |
| Storage | Store at -20°C. Open under aseptic conditions. |