SEC inhibitor KL-2
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-123972-10 mg |
| CAS # | 900308-51-2 |
| Pricing | 10 mg, USD $550.0 |
| Synonyms | KL-2 |
| MWt | 333.74 |
| Formula | C₁₇H₁₃ClFNO₃ |
| Biological Activity | SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1]. |
| Purity | ≥99.0% |