Doxorubicin, Hydrochloride Salt (Adriacin, Adriamycin, Adriblastin, Adriblastina, Dox, Doxil, Farmiblastina, 14-Hydroxydaunomycin, 14-Hydroxydaunorubicine, FI-106, Lipodox, Myocet, NSC-123127, Rubex, CAS 25316-40-9), >99%

LC Laboratories' Product Number D-4000 - Doxorubicin, Hydrochloride Salt (Adriacin, Adriamycin, Adriblastin, Adriblastina, Caelyx, Dox, Doxil, Farmiblastina, 14-Hydroxydaunomycin, FI-106, Lipodox, Myocet, NSC-123127, Rubex, CAS 25316-40-9), >99% - for research use only. Doxorubicin is an anthracycline antibiotic. It is used in the treatment of a wide range of cancers. Doxorubicin inhibited DNA and RNA but not protein synthesis in intact cells. Doxorubicin-conjugated HIV(P4/D10) antibody neutralized HIV-1IIIB and inhibited HIV replication in vitro. It also protected mice from challenge with HIV-1IIIB/MuLV in vivo. Combination with estradiol was found to enhance the apoptotic action of doxorubicin in estrogen-resistant MCF-7/LS cells but not in the estrogen-dependent MCF-7 breast cancer cells. NF-κB may be a potential target for estradiol and doxorubicin in the therapy of the resistant breast cancer. When patients were treated for breast or ovarian cancer, lymphoma, myeloma or sarcoma, the risk of cardiotoxicity was significantly greater with doxorubicin-containing regimens and bolus administration than non-anthracycline regimens. Doxorubicin hydrochloride is the active ingredient in the drug sold under the tradenames Adriamycin PFS, Adriamycin RDF, or Rubex®. This drug has been approved in at least one country for use in patients with a wide range of cancers. NOTE: The doxorubicin hydrochloride sold by LC Laboratories is NOT Adriamycin or Rubex®, and is NOT for human use. Our doxorubicin product is the hydrochloride salt, whose CAS number is given above. The CAS number of the free base is 23214-92-8. Other CAS numbers previously assigned to doxorubicin, namely 23257-17-2, 24385-08-8, 25311-50-6, and 29042-30-6, have been deleted by CAS and are no longer in use.

• Supplier: LC Laboratories
• Product #: D-4000
• Sku #: D-4000_5g