Ro 25-6981 HCl
Ro 25-6981 is a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Ro 25-6981 inhibited 3H-MK-801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0.003 microM and 149 microM for high- (about 60%) and low-affinity sites, respectively. NMDA receptor subtypes expressed in Xenopus oocytes were blocked with IC50 values of 0.009 microM and 52 microM for the subunit combinations NR1C & NR2B and NR1C & NR2A, respectively, which indicated a >5000-fold selectivity.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1143 |
| CAS # | 919289-58-0 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Ro 256981 HCl; Ro 25 6981 HCl; Ro 25-6981 HCl |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C22H30ClNO2 |
| Exact Mass | 375.1965 |
| Molecular Weight | 375.937 |
| Elemental Analysis | C, 70.29; H, 8.04; Cl, 9.43; N, 3.73; O, 8.51 |
| IUPAC/Chemical Name | 4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol hydrochloride |
| InChi Key | MKTZWXWTQQOMSH-OTCZLQCGSA-N |
| InChi Code | InChI=1S/C22H29NO2.ClH/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H/t17-,22+;/m0./s1 |
| SMILES Code | OC1=CC=C([C@H](O)[C@@H](C)CN2CCC(CC3=CC=CC=C3)CC2)C=C1.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |