D-Thyroxine
D-Thyroxine is the dextrorotary isomer of thyroxine with antihyperlipidemic activity. It stimulates the formation of low-density lipoprotein (LDL) and increases the catabolism of LDL thereby leading to increased excretion of cholesterol and bile acids via the biliary route. It is released from thyroglobulin by proteolysis and secreted into the blood. It is one of the thyroid hormones involved in the maintenance of metabolic homeostasis and has been used to treat hyperlipidemia. It is used as an cholesterol-lowering drug but was pulled due to cardiac side-effects. It also increases hepatic lipase which in turn improves utilization of triglycerides, improving apolipoprotein E cholesterol particles.
| Supplier | BOC Sciences |
|---|---|
| Product # | 51-49-0 |
| Pricing | Inquire |
| Cas | 51-49-0 |
| Molecular Weight | 776.87 |
| Molecular Formula | C15H11I4NO4 |
| Canonical SMILES | C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N |