SKI II
2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2, hPI3K, or hPKCα at concentrations up to 60 μM. SK1-II showed anti-tumor properties, inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins.
| Supplier | BOC Sciences |
|---|---|
| Product # | 312636-16-1 |
| Pricing | Inquire |
| Cas | 312636-16-1 |
| Molecular Weight | 302.78 |
| Molecular Formula | C15H11ClN2OS |
| Canonical SMILES | C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl |