Tipepidine
Tipepidine, also known as tipepidine hibenzate, is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). Tipepidine has recently garnered interest as a potential psychiatric drug. It is being investigated in depression, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder (ADHD). Through inhibition of GIRK channels, tipepidine increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD012 |
| CAS # | 5169-78-8 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | Tipepidine; AT 327; AT-327; AT327; brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C15H17NS2 |
| Exact Mass | 275.0802 |
| Molecular Weight | 275.43 |
| Elemental Analysis | C, 65.41; H, 6.22; N, 5.09; S, 23.28 |
| IUPAC/Chemical Name | 3-(Di-2-thienylmethylene)-1-methylpiperidine |
| InChi Key | JWIXXNLOKOAAQT-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C15H17NS2/c1-16-8-2-5-12(11-16)15(13-6-3-9-17-13)14-7-4-10-18-14/h3-4,6-7,9-10H,2,5,8,11H2,1H3 |
| SMILES Code | CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.03.00 |
| Class-2 | Depression |