Cadherin-1 / E-Cadherin (CDH1) Antibody
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells.There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins.In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation.Its association with catenins is necessary for cell-cell adhesion.These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques.Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties.E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas.Increased expression of E-Cadherin in these cells reduces invasiveness.Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Supplier | Abbexa Ltd. |
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Product # | abx015807-100UL |
Pricing | 100 µl USD $420.5 |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Host | Mouse |
Tested Applications | ELISA, WB |
Dry Ice | No |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |