Cadherin-1 / E-Cadherin (CDH1) Antibody
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells.There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins.In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation.Its association with catenins is necessary for cell-cell adhesion.These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques.Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties.E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas.Increased expression of E-Cadherin in these cells reduces invasiveness.Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
| Supplier | Abbexa Ltd. |
|---|---|
| Product # | abx015807-100UL |
| Pricing | 100 µl USD $420.5 |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Host | Mouse |
| Tested Applications | ELISA, WB |
| Dry Ice | No |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |