Active Recombinant Human B-cell CLL/lymphoma 10

Bcl-10 is an intracellular signaling protein identified from the t (p22;q32) breakpoint in MALT lymphomas. The human Bcl-10 gene encodes a protein of 233 amino acids containing an N-terminal Caspase Recruitment Domain (CARD) that mediates self-oligomerization and the Cterminal region of Bcl-10. Bcl-10 is expressed ubiquitously with highexpression levels in lymphoid tissues and in the developing central nerve system. Mutations have been found in cases of follicular lymphoma and diffuse large B cell lymphoma. Bcl-10 is a positive regulator of antigenreceptor induced NF-B activation and Bcl-10-initiated activation of NF-B can be inhibited by cotransfection of dominant-negative mutants of TRAF2, NIK, IKKa or IkBa. The wild type human Bcl-10 protein was expressed in baculovirus system and purified by an affinity column in combination with FPLC chromatography. Purified protein is greater than 95% homogeneous and contains no detectable proteases, DNase, and RNase activity.

• Supplier: Creative Biomart
• Product #: BCL10-1016H