| Supplier |
CD BioSciences |
| Product # |
AMA-0723 |
| Pricing |
20 µL/100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, IP, IF
|
| Product Usage Information Dilution |
Western Blotting (1:1000); Immunoprecipitation (1:50); Immunofluorescence (1:1600)
|
| Reactivity |
Human, Mouse, Rat, Monkey
|
| Host |
Rabbit
|
| Gene ID |
3693
|
| UniProt ID |
|
| Source/Isotype |
Rabbit IgG
|
| MW (Target) |
90 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys789 of human integrin β5 protein.
|
| Background |
Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins having distinct tissue distribution and overlapping ligand specificities Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling)The αVβ5 integrin is expressed in various tissues and cell types, including endothelia, epithelia and fibroblasts It plays a role in matrix adhesion to VN, FN, SPARC and bone sialoprotein and functions in the invasion of gliomas and metastatic carcinoma cells αVβ5 integrin plays a major role in growth-factor-induced tumor angiogenesis, where cooperative signaling by the αVβ5 integrin and growth factors regulates endothelial cell proliferation and survival.
|