Afuco™ Anti-Human Integrin α5β1 ADCC Therapeutic Antibody (PF-04605412), ADCC Enhanced
Anti-Integrin α5β1 ADCC Enhanced Antibody (PF-04605412) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a fully human, fragment crystalizable (Fc)-engineered IgG1 mAb, which specifically neutralizes α5 and binds the Fcγ receptors (FcγR) with enhanced affinity. In vitro, PF-5412 potently inhibited α5β1-mediated intracellular signaling, cell adhesion, migration, and endothelial cell (EC) tubulogenesis. The dual mechanism of action and robust antitumor efficacy of PF-5412 support its clinical development for the treatment of a broad spectrum of human malignancies.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AFC-425CL |
| Pricing | Inquiry |
| Host | Human |
| Target | Integrin α5β1 |
| Species Reactivity | Human |
| Type | ADCC enhanced antibody |
| Storage | ≤1 year at -20°C. |