BI-882370
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-107779-100 mg |
| CAS # | 1392429-79-6 |
| Pricing | 100 mg, USD $970.0 |
| Biological Activity | BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases[1]. |
| Purity | 99.16% |
| MWt | 569.67 |
| Formula | C₂₈H₃₃F₂N₇O₂S |