Decoglurant
Decoglurant, also known as Ro 4995819, is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant progressed as far as phase II clinical trials but was ultimately discontinued from further development due to disappointing efficacy results.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD172 |
| CAS # | 911115-16-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | Ro-4995819; Ro4995819; Ro4995819; Decoglurant. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H11F6N5 |
| Exact Mass | 447.0919 |
| Molecular Weight | 447.3444 |
| Elemental Analysis | C, 56.38; H, 2.48; F, 25.48; N, 15.66 |
| IUPAC/Chemical Name | 5-((7-(trifluoromethyl)-5-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)ethynyl)pyridin-2-amine |
| InChi Key | DMJHZVARRXJSEG-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29) |
| SMILES Code | NC1=NC=C(C#CC2=C3N=C(C4=CC=C(C(F)(F)F)C=C4)C=C(C(F)(F)F)N3N=C2)C=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |