Nelivaptan
Nelivaptan is a non-peptide vasopressin receptor antagonist that is selective for the V1B subtype. SSR149415 ameliorates spermatogenesis function in a mouse model of chronic social defeat stress. SSR149415 has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model. SSR149415 blocks aggressive behaviors in hamsters. The combination of V1b antagonist SSR149415 with NTN at individual subthreshold doses shows potential in alcoholism treatment, possibly with less adverse effects.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD319 |
| CAS # | 439687-69-1 |
| Pricing | Customizable size, Inquiry |
| Synonym | Nelivaptan; SSR149415; SR-149415; SR 149415; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C30H32ClN3O8S |
| Exact Mass | 629.1599 |
| Molecular Weight | 630.109 |
| Elemental Analysis | C, 57.19; H, 5.12; Cl, 5.63; N, 6.67; O, 20.31; S, 5.09 |
| IUPAC/Chemical Name | (2S,4R)-1-[(3R)-5-Chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide |
| InChi Key | NJXZWIIMWNEOGJ-WEWKHQNJSA-N |
| InChi Code | InChI=1S/C30H32ClN3O8S/c1-32(2)28(36)24-15-19(35)17-33(24)30(21-8-6-7-9-25(21)41-4)22-14-18(31)10-12-23(22)34(29(30)37)43(38,39)27-13-11-20(40-3)16-26(27)42-5/h6-14,16,19,24,35H,15,17H2,1-5H3/t19-,24+,30+/m1/s1 |
| SMILES Code | O=C([C@H]1N([C@]2(C3=CC=CC=C3OC)C(N(S(=O)(C4=CC=C(OC)C=C4OC)=O)C5=C2C=C(Cl)C=C5)=O)C[C@H](O)C1)N(C)C |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |
| Availability | 2 Weeks |