F13714 free base
F13714 is a Serotonin 5-HT1A Receptor Agonist. F13714 shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress. F13714 has a high affinity (0.1 nM) and selectivity for 5-HT(1A) receptors. In vitro (18)F-F13714 binding in rats was consistent with the known 5-HT(1A) receptors distribution (hippocampus and cortical areas) and was particularly high in the dorsal raphe. In vitro binding of (18)F-F13714 was blocked in a dose-dependent fashion by WAY100635, the prototypical 5-HT(1A) antagonist, and by the endogenous agonist, serotonin (5-HT). Addition of Gpp(NH)p also inhibited in vitro (18)F-F13714 binding, consistent with a preferential binding of the compound to G-protein-coupled receptors. Ex vivo tissue measurements in rat revealed an absence of brain radioactive metabolites.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD844 |
| CAS # | 208109-38-0 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | F13714; F-13714; F 13714; F 14679; F-14679; F14679; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H25ClF2N4O |
| Exact Mass | 422.1685 |
| Molecular Weight | 422.9048 |
| Elemental Analysis | C, 59.64; H, 5.96; Cl, 8.38; F, 8.98; N, 13.25; O, 3.78 |
| IUPAC/Chemical Name | 3-chloro-4-fluorophenyl-(4-fluoro-4-(((5-methyl-6-methylaminopyridin-2-ylmethyl)amino)methyl)piperidin-1-yl)methanone |
| InChi Key | QILKJZOYDVAGPZ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C21H25ClF2N4O/c1-14-3-5-16(27-19(14)25-2)12-26-13-21(24)7-9-28(10-8-21)20(29)15-4-6-18(23)17(22)11-15/h3-6,11,26H,7-10,12-13H2,1-2H3,(H,25,27) |
| SMILES Code | O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCC3=NC(NC)=C(C)C=C3)(F)CC2 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |