| Supplier |
CD Formulation |
| Product # |
PE-0484 |
| Pricing |
, Inquire for price
|
| product1 |
Pharmaceutical Excipients
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| Molecular Formula |
C4H4KNO4S
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| Molecular Weight |
201.24
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| Applications |
Acetylsul panpotassium is a strong sweetener used in cosmetics, foods, beverages, sweet flavorings, vitamins and pharmaceutical preparations (including powder, tablet and liquid preparations). It is widely used as a sugar substitute in compound preparations and as a sweetener in toothpaste. Its sweetness is about 180 to 200 times that of sucrose. It corrects the taste and covers up some undesirable tastes.
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| CAS Number |
55589-62-3
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| Category |
Sweetening agent
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| Chemical Name |
6-Methyl-1, 2, 3-oxathiazin-4(3H)-one-2, 2-dioxide potassium salt
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| Grade |
Pharmceutical Excipients
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| Administration route |
Oral
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| Dosage Form |
Oral preparations
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| Stability and Storage Conditions |
Acetylsul panpotassium has good stability. Stored in bulk at room temperature for many years without signs of decomposition. The sweetness of aqueous solution (pH 3.0 - 3.5, 20℃) did not decrease for about two years. Although some decomposition after storage at 40℃ for several months, it has good stability at temperature rise. Neither sterilization nor pasteurization affected the sweetness of acetylsulpanpotassium. Bulk products should be stored in airtight containers in a dry place.
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| Source and Preparation |
Acetylsul panpotassium is synthesized from tert-butyl acetoacetate and fluorosulfonyl isocyanate. The resulting product is converted to fluorosulfonyl acetoacetamide and cyclized into dioxythiazone cyclization in the presence of potassium hydroxide. Because this compound is strongly acidic, it can directly form potassium salt. Another route for the synthesis of acetylsulfamide begins with the reaction of dienone and sulfamic acid. In the presence of dehydrating agent, acetyl sulpanitum potassium is produced after neutralization with potassium hydroxide.
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