Recombinant Human Anti-HIV-1 gp120 Antibody (PGT122)
Recombinant Human Antibody (PGT122) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-HIV-1 gp120 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. PGT121 family, which was previously shown to neutralize approximately 70% of circulating HIV-1 isolates and recognizes an N332-dependent epitope on the gp120 outer domain. PGT121 antibodies inhibit CD4 binding to gp120 despite the epitope being distal from the CD4 binding site.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABZ-161 |
| Pricing | Inquiry |
| Host | Human |
| Target | HIV-1 gp120 |
| Species Reactivity | HIV-1 |
| Type | IgG |
| Applications |
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| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples. |