Glutamate Receptor Endocytosis Inhibitor, GluR23Y

• Supplier: Creative Peptides
• Product #: X21193
• MolecularWeight: 1092.2
• Sequence:
  • One Letter Code: YKEGYNVYG
  • Three Letter Code: H-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH
• Storage: -20°C
• Explanation: This GluR23Y peptide was used in ELISA cell-surface assay for the insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y prevented any insulin-induced reduction. The blockade of insulin action was observed when the GluR23Y peptide was delivered into neurons by fusing it to the membrane transduction domain of HIV-1.
• Reference:
  • 1. Ahmadian, G. et al. EMBO J. 23, 1040 (2004),
  • 2. Wang, D. et al. J. Biol. Chem. 279, 41267 (2004).