Recombinant Human ALK1 (N-GST tag)

ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGF汕 superfamily. ALK1 functions as a TGF汕 type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGF汕 signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported.

• Supplier: Amerigo Scientific
• Product #: Z500009