LY2607540
LY2607540, also known as THIIC, is a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties (EC(50) = 23 and 13 nM, respectively). THIIC produced anxiolytic-like efficacy in the rat stress-induced hyperthermia assay and the mouse stress-induced elevation of cerebellar cGMP and marble-burying assays. THIIC also produced robust activity in three assays that detect antidepressant-like activity, including the mouse forced-swim test, the rat differential reinforcement of low rate 72-s assay, and the rat dominant-submissive test, with a maximal response similar to that of imipramine.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD961 |
| CAS # | 1204737-09-6 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | LY2607540; LY-2607540; LY 2607540; THIIC |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C24H24F3N3O4 |
| Exact Mass | 475.1719 |
| Molecular Weight | 475.4682 |
| Elemental Analysis | C, 60.63; H, 5.09; F, 11.99; N, 8.84; O, 13.46 |
| IUPAC/Chemical Name | N-({4-[3-hydroxy-4-(2-methylpropanoyl)-2-(trifluoromethyl)phenoxymethyl]phenyl}methyl)-1-methyl-1H-imidazole-4-carboxamide |
| InChi Key | RYINQFMHVVYWNS-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C24H24F3N3O4/c1-14(2)21(31)17-8-9-19(20(22(17)32)24(25,26)27)34-12-16-6-4-15(5-7-16)10-28-23(33)18-11-30(3)13-29-18/h4-9,11,13-14,32H,10,12H2,1-3H3,(H,28,33) |
| SMILES Code | O=C(C1=CN(C)C=N1)NCC2=CC=C(COC3=CC=C(C(C(C)C)=O)C(O)=C3C(F)(F)F)C=C2 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |