anti-MSLN immunotoxin K1 (IgG)-PE
This immunotoxin was achieved by conjugating/fusing the Anti-MSLN monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to ovarian cancer and malignant mesothelioma cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of ovarian cancer and malignant mesothelioma.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-L035E |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | MSLN |
| Species Reactivity | Human |