Fingolimod, Hydrochloride Salt (FTY-720A, FTY720, Gilenia, Gilenya, CAS 162359-56-0), >99%

LC Laboratories' Product Number F-4633 - Fingolimod, Hydrochloride Salt (FTY-720A, FTY720, Gilenia, Gilenya, CAS 162359-56-0), >99% - for research use only. Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) analog, is a novel immunosuppressant drug that induces lymphopenia by preventing emergence of lymphocytes from lymph nodes. Fingolimod is a sphingosine-1-phosphate receptor 1 modulator and is in phase III clinical trials for relapsing-remitting multiple sclerosis. Suppresses allotransplant rejections and autoimmune disorders in different animal models. Fingolimod appears to promote the survival of human and animal allografts by sequestering T lymphocytes within peripheral lymphoid tissue. Evidence for this mechanism of sequestration includes: (1) fingolimod drives T lymphocytes into peripheral lymph nodes in a chemokine dependent manner; (2) fingolimod downregulates sphingosine 1-phosphate receptors (S1PRs) on the T lymphocyte surface, preventing it from migrating along a S1P gradient; and (3) fingolimod blocks stromal gates on the abluminal side of the lymphatic endothelium.

• Supplier: LC Laboratories
• Product #: F-4633
• Sku #: F-4633_300mg