Bax (2D2) Mouse Antibody
| Supplier | CD BioSciences |
|---|---|
| Product # | AMA-0273 |
| Pricing | 100 µL, Inquire |
| Product Category | Antibodies |
| Application | WB, IP, IF |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:100); Immunofluorescence (1:6400) |
| Reactivity | Human |
| Host | Mouse |
| Gene ID | 581 |
| UniProt ID | |
| Source/Isotype | Mouse IgG1 |
| MW (Target) | 20 kDa |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the N-terminal region of human Bax protein. |
| Background | Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9, and initiation of the caspase activation pathway for apoptosis. |