BMS-1166-N-piperidine-COOH
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-131187 |
| CAS # | 2447066-00-2 |
| Pricing | inquire |
| Biological Activity | BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1[1]. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[2]. |
| MWt | 639.14 |
| Formula | C₃₇H₃₅ClN₂O₆ |