Clobenpropit HBr
Clobenpropit, also known as VUF 9153, is a highly potent H3 antagonist and H4 partial agonist. Clobenpropit has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats. Clobenpropit promises neuroprotection against LPS-induced cognitive deficits by meliorating neuroinflammation and restoring the MRCC enzymes in mice. Clobenpropit protects propofol-induced apoptosis of hippocampal neurons through PI3K/AKT pathway.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD740 |
| CAS # | 145231-35-2 (2HBr) |
| Pricing | Customizable size, Inquiry |
| Synonym | Clobenpropit HBr; Clobenpropit dihydrobromide; VUF 9153; VUF-9153; VUF9153; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C14H19Br2ClN4S |
| Exact Mass | 467.9386 |
| Molecular Weight | 470.652 |
| Elemental Analysis | C, 35.73; H, 4.07; Br, 33.95; Cl, 7.53; N, 11.90; S, 6.81 |
| IUPAC/Chemical Name | 3-(1H-imidazol-4-yl)propyl (4-chlorobenzyl)carbamimidothioate dihydrobromide |
| InChi Key | JIJQPEZAVLJZBO-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C14H17ClN4S.2BrH/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13;;/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);2*1H |
| SMILES Code | ClC1=CC=C(CNC(SCCCC2=CNC=N2)=N)C=C1.[H]Br.[H]Br |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |