Duvelisib, Free Base (INK-1197, IPI-145, CAS 1201438-56-3), >99%

LC Laboratories' Product Number D-8147 - Duvelisib, Free Base (INK-1197, IPI-145, CAS 1201438-56-3), >99% - for research use only. Duvelisib, also known as IPI-145, is a potent inhibitor of phosphoinositide-3-kinase (PI3K) δ and PI3K γ. It inhibits PI3K δ and γ with Ki values of 23 and 243 pM, cell-free IC50 values of 2.5 and 27.4 nM, and cellular IC50 values of 1 nM and 43 nM, respectively. It was active in preclinical models of arthritis. Duvelisib was active and well-tolerated in patients with relapsed/refractory peripheral and cutaneous T-cell lymphomas. A phase I trial demonstrated that duvelisib was well tolerated and showed initial clinical activity in patients with indolent non-Hodgkin's lymphoma, mantle cell lymphoma, and chronic lymphocytic leukemia. Other CAS numbers previously assigned to IPI-145 free base, namely 1355213-59-0 and 1428465-12-6, have been deleted by CAS and are no longer in use.

• Supplier: LC Laboratories
• Product #: D-8147
• Sku #: D-8147_5mg