p14 ARF (4C6/4) Mouse Antibody

Supplier CD BioSciences
Product # AMA-0288
Pricing 100 µL, Inquire
Product Category Antibodies
Application WB, IHC
Product Usage Information Dilution Western Blotting (1:1000); Immunohistochemistry (1:50)
Reactivity Human
Host Mouse
Gene ID 1029
UniProt ID
Source/Isotype Mouse IgG2a
MW (Target) 14 kDa
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a recombinant His-tagged p14 ARF protein.
Background Human p14 ARF (p19 ARF in mouse) is a pro-apoptotic cell cycle regulator frequently inactive in human tumors. Basal expression of p14 ARF is low in most cell types, but accumulation of this protein occurs in response to oncogene expression. Increased p14 ARF levels facilitate MDM2 degradation, leading to increased p53 protein levels and subsequent cell cycle arrest and/or apoptosis. While most p14 ARF signaling has traditionally thought to be p53-dependent, more recent reports have described p53-independent p14 ARF signaling leading to cell cycle arrest and apoptosis.
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