Active Recombinant Mouse Cd40, His-tagged

The CD40 molecule is a 45- 50-kDa type I phosphorylated glycoprotein that belongs to the tumor necrosis factor receptor superfamily and was initially considered to be a growth factor receptor on B cells. The interaction of CD40 with its natural ligand, CD154, is a crucial step in T cell-dependent B cell activation and differentiation. The cellular events triggered in CD40-positive cells following CD40/CD154 interactions are not restricted to B cells only but can also be triggered in dendritic cells, monocytes, epithelial cells, endothelial cells, and fibroblasts. Thus, CD40 ligation mediates a broad variety of immune and inflammatory responses.

• Supplier: Creative Biomart
• Product #: Cd40-86M