Guanfu base A
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-N1483 |
| CAS # | 1394-48-5 |
| Pricing | inquire |
| Biological Activity | Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2]. |
| MWt | 429.51 |
| Formula | C₂₄H₃₁NO₆ |