Bisindolylmaleimide VIII acetate
Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor with IC50 of 158 nM for rat brain that acts at the ATP binding site. Bis VIII has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism. BIM VIII does not inhibit the tyrosine phosphorylation or the activation of phospholipase C γ1. BIM VIII inhibits carbachol-evoked noradrenaline release from human SH-SY5Y neuroblastoma cells with an IC50 of 600 nM.
| Supplier | BOC Sciences |
|---|---|
| Product # | 138516-31-1 |
| Pricing | Inquire |
| Cas | 138516-31-1 |
| Molecular Weight | 458.5 |
| Molecular Formula | C24H22N4O2·C2H4O2 |
| Canonical SMILES | O=C(N1[H])C(C2=CN(C)C3=C2C=CC=C3)=C(C4=CN(CCCN)C5=C4C=CC=C5)C1=O.CC(O)=O |