Butein
Supplier | MedChemExpress |
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Product # | HY-16558-10 mg |
CAS # | 487-52-5 |
Pricing | 10 mg, USD $144.0 |
Synonyms | 2’,3,4,4’-tetrahydroxy Chalcone |
MWt | 272.25 |
Formula | C₁₅H₁₂O₅ |
Biological Activity | Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4[1]. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells[2]. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a[3]. Butein is a SIRT1 activator (STAC). |
Purity | 99.95% |