PAP-1
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-10015-10 mg |
| CAS # | 870653-45-5 |
| Pricing | 10 mg, USD $162.0 |
| Synonyms | 5-(4-Phenoxybutoxy)psoralen |
| MWt | 350.36 |
| Formula | C₂₁H₁₈O₅ |
| Biological Activity | PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects[1][2]. |
| Purity | 99.69% |