3-Hydroxy Midostaurin
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-108263-5 mg |
| CAS # | 179237-49-1 |
| Pricing | 5 mg, USD $1150.0 |
| Biological Activity | 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1]. |
| Synonyms | CGP52421 |
| MWt | 586.64 |
| Formula | C₃₅H₃₀N₄O₅ |