| Supplier |
CD BioSciences |
| Product # |
AMA-0037 |
| Pricing |
100 μL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB
|
| Product Usage Information Dilution |
Western Blotting (1:1000)
|
| Reactivity |
Human, Monkey, Mouse, Rat, Hamster, Bovine, Dog, Pig
|
| Host |
Rabbit
|
| Gene ID |
6197
|
| UniProt ID |
|
| Source/Isotype |
Rabbit IgG
|
| MW (Target) |
90 kDa
|
| Storage |
Store at -20°C.
|
| Purification |
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro583 of human RSK1 protein (Pro587 in hRSK2, Pro580 in hRSK3).
|
| Background |
The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation. RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters.
|