VU6009453
VU6009453 is a novel M4 positive allosteric modulator (PAM). VU6009453 showed good potency (EC50=383 nM) and excellent CNS penetration (rat Kp=3.4, Kp,uu=0.84).
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1761 |
| CAS # | 2148929-11-5 |
| Pricing | Customizable size, Inquiry |
| Synonym | VU6009453; VU 6009453; VU-6009453 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H21ClN4O2 |
| Exact Mass | 396.1353 |
| Molecular Weight | 396.88 |
| Elemental Analysis | C, 63.55; H, 5.33; Cl, 8.93; N, 14.12; O, 8.06 |
| IUPAC/Chemical Name | N-(1-(5-Chloro-2-methoxypyridin-4-yl)azetidin-3-yl)-2,4-dimethylquinoline-6-carboxamide |
| InChi Key | NVGMPSJSLKIVIT-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C21H21ClN4O2/c1-12-6-13(2)24-18-5-4-14(7-16(12)18)21(27)25-15-10-26(11-15)19-8-20(28-3)23-9-17(19)22/h4-9,15H,10-11H2,1-3H3,(H,25,27) |
| SMILES Code | O=C(C1=CC=C2N=C(C)C=C(C)C2=C1)NC3CN(C4=CC(OC)=NC=C4Cl)C3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.03.00 |