| Supplier |
Creative Peptides |
| Product # |
10-101-110 |
| CAS # |
24359-81-7 |
| Pricing |
Inquire
|
| Synonyms |
2-(N-Phenyl-N-benzyl-aminomethyl)imidazoline · sulfate; 2-[(N-Benzylanilino)methyl]-2-imidazoline · sulfate; 4,5-Dihydro-N-phenyl-N-(phenylmethyl)-1H-imidazole-2-methanamine · sulfate
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| MolecularFormula |
C17H19N3·H2O4S
|
| MolecularWeight |
363.35
|
| Source |
Synthetic
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| ShippingCondition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
|
| Explanation |
Antistine-Privine (Antazoline Sulfate) is a 1st generation antihistamine, with good anticholinergic properties. It is used to relieve nasal congestion and added in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
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| ChemicalName |
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;sulfuric acid
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| Application |
Conjunctivitis
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| Activity |
Antagonist
|
| InChI |
InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)
|
| InChIKey |
REYFJDPCWQRWAA-UHFFFAOYSA-N
|
| CanonicalSMILES |
C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3.OS(=O)(=O)O
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| Solubility |
Soluble in DMSO
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| Appearance |
Solid powder
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| Target |
Histamine H1 receptor
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| Reference |
- Antazoline seems to be safe agent in termination of AF in patients undergoing pulmonary vein isolation. We also observed satisfying efficacy, which needs to be proved in a randomized clinical trial.
- Balsam P, Koźluk E, Peller M, et al. Antazoline for termination of atrial fibrillation during the procedure of pulmonary veins isolation[J]. Advances in medical sciences, 2015, 60(2): 231-235.
- Intravenous antazoline was effective and safe in the rapid conversion of non-valvular paroxysmal atrial fibrillation to sinus rhythm in patients without heart failure.
- Maciag A, Farkowski M M, Chwyczko T, et al. Efficacy and safety of antazoline in the rapid cardioversion of paroxysmal atrial fibrillation (the AnPAF Study)[J]. EP Europace, 2016: euw384.
- Antazoline is an old antihistaminic and new antiarrhythmic agent with unknown mechanisms of action which recently has been shown to effectively terminate atrial fibrillation. The aim of study was to examine the effects of antazoline on hemodynamic and ECG parameters.
- Piotrowski R, Giebułtowicz J, Baran J, et al. Antazoline—insights into drug‐induced electrocardiographic and hemodynamic effects: Results of the ELEPHANT II substudy[J]. Annals of Noninvasive Electrocardiology, 2017.
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| Purity |
>98% (or refer to the Certificate of Analysis)
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| AreasOfInterest |
Neurological Disease
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| ShortTermStorageConditions |
Dry, dark and at 0 - 4 °C
|
| LongTermStorageConditions |
-20 °C
|
| LabelingTarget |
Histamine Receptor
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| BoilingPoint |
475.5±38.0 °C at 760 mmHg
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| MeltingPoint |
159ºC
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