Piromelatine
Piromelatine, also known as NEU-P11, is a multimodal sleep drug under development by Neurim Pharmaceuticals. It is an agonist at melatonin MT1/MT2 and serotonin 5-HT1A/5-HT1D receptors. Pre-clinical studies showed antinociceptive, antihypertensive and cognitive benefits in rat disease models of pain, hypertension, and Alzheimer's disease.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1327 |
| CAS # | 946846-83-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | NEU-P11; NEU-P 11; NEU-P-11; Piromelatine |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C17H16N2O4 |
| Exact Mass | 312.111 |
| Molecular Weight | 312.325 |
| Elemental Analysis | C, 65.38; H, 5.16; N, 8.97; O, 20.49 |
| IUPAC/Chemical Name | N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-4-oxo-4H-pyran-2-carboxamide |
| InChi Key | PNTNBIHOAPJYDB-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C17H16N2O4/c1-22-13-2-3-15-14(9-13)11(10-19-15)4-6-18-17(21)16-8-12(20)5-7-23-16/h2-3,5,7-10,19H,4,6H2,1H3,(H,18,21) |
| SMILES Code | O=C(C1=CC(C=CO1)=O)NCCC2=CNC3=C2C=C(OC)C=C3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |